Allopurinol 300mg (Zyloric) Tablets

Allopurinol 300mg (Zyloric) is an effective medication used for the management of gout and hyperuricemia (elevated uric acid levels in the blood). As a xanthine oxidase inhibitor, Allopurinol works by reducing the production of uric acid in the body. High levels of uric acid can lead to the formation of crystals in the joints, causing painful gout attacks and associated complications. By lowering uric acid levels, Zyloric helps prevent the occurrence of gout flares and complications related to hyperuricemia.

Indications:

Allopurinol 300mg (Zyloric) is indicated for:

• The treatment of gout and chronic hyperuricemia
• Prevention of gout attacks and related complications
• Management of elevated uric acid levels in patients undergoing chemotherapy or radiation therapy, especially to prevent tumor lysis syndrome

Dosage and Administration:

• Recommended Dose: The typical starting dose for adults is 300mg per day, taken orally. The dose may be adjusted based on individual uric acid levels and patient response, with a maximum daily dose of 800mg being permissible in some cases.
• Allopurinol should be taken after meals with a full glass of water to minimize gastrointestinal side effects.
• Regular monitoring of uric acid levels is important to assess treatment effectiveness and adjust the dosage as needed.

Contraindications:

• Hypersensitivity to Allopurinol or any of its components
• Patients experiencing an acute gout attack should not start Allopurinol until the attack has resolved
• Severe liver or kidney dysfunction may require special caution and dosage adjustments

Precautions:

• Use with caution in patients with renal impairment; dosage adjustments may be necessary.
• It is essential for patients to stay well-hydrated while taking Allopurinol to help prevent kidney stones.
• Initiating Allopurinol therapy during an acute gout attack may worsen symptoms; therefore, treatment is typically delayed until the attack resolves.
• Discontinue use and seek medical attention if a rash or allergic reaction occurs, as this may indicate a serious condition like Stevens-Johnson syndrome.

Side Effects:

Common side effects may include:

• Nausea or gastrointestinal upset
• Diarrhea
• Drowsiness
• Skin rash

Serious side effects (seek medical attention if these occur):

• Severe allergic reactions (rash, itching, swelling, difficulty breathing)
• Liver function abnormalities (jaundice, dark urine)
• Blood disorders (fever, sore throat, unusual bruising or bleeding)

Drug Interactions:

• Caution is advised when combining Allopurinol with medications that can affect kidney function or uric acid metabolism, such as azathioprine and mercaptopurine, as Allopurinol can increase their toxicity.
• Diuretics may heighten the risk of gout attacks when starting Allopurinol.
• Monitoring may be necessary for patients on warfarin and other anticoagulants, as Allopurinol can alter their effects.

Storage:

• Store at room temperature, away from direct sunlight and moisture.
• Keep out of reach of children.

Packaging:

• Allopurinol 300mg (Zyloric) is available in blister packs or bottles, typically containing 10, 28, or 30 tablets.