Hydroxychloroquine 200 mg Tablets

Hydroxychloroquine 200mg Tablets are an antimalarial and immunomodulatory medication primarily used for the prevention and treatment of malaria. This medication is also effective in managing autoimmune disorders, such as rheumatoid arthritis and systemic lupus erythematosus (SLE). Hydroxychloroquine belongs to the 4-aminoquinoline class and is known for its ability to reduce inflammation and modulate immune system activity.

Indications:

Hydroxychloroquine is indicated for:

• Malaria: Used for both the prevention and treatment of malaria caused by Plasmodium species, particularly in regions where chloroquine resistance is not prevalent.
• Rheumatoid Arthritis: Helps in reducing symptoms like pain and swelling in adults.
• Systemic Lupus Erythematosus (SLE): Aids in managing flares and decreasing disease activity in lupus patients.

Dosage and Administration:

• For Malaria Prevention: The typical dosage is 400 mg (two 200 mg tablets) once weekly, starting 1-2 weeks before travel to an endemic area and continuing for 4 weeks after leaving.
• For Acute Malaria Treatment: A loading dose may be required, followed by a specific dosing schedule based on weight and clinical guidelines.
• For Rheumatoid Arthritis and SLE: The usual starting dose is 400-600 mg daily (two to three 200 mg tablets), with adjustments based on the patient’s response.
• Hydroxychloroquine should be taken with food or milk to minimize gastrointestinal irritation.

Contraindications:

• Hypersensitivity to hydroxychloroquine or any of its components.
• Patients with known retinal or visual field changes due to prior use of 4-aminoquinolines.

Precautions:

• Ophthalmic Monitoring: Regular eye examinations are essential due to the potential risk of retinal toxicity, especially with long-term use.
• Cardiac Considerations: Use with caution in patients with a history of heart rhythm disorders or those on medications that may prolong the QT interval.
• Pregnancy and Lactation: The use of hydroxychloroquine during pregnancy and breastfeeding should be discussed with a healthcare provider to weigh potential benefits against risks.

Side Effects:

Common side effects may include:

• Nausea and vomiting
• Diarrhea
• Stomach cramps
• Dizziness
• Headache

Serious side effects (seek immediate medical attention if these occur):

• Vision changes (e.g., blurred vision, difficulty seeing)
• Severe skin reactions (e.g., rash, blistering)
• Muscle weakness or pain
• Signs of liver toxicity (e.g., jaundice, dark urine)

Drug Interactions:

• Hydroxychloroquine may interact with other medications, particularly those affecting the heart rhythm. Inform your healthcare provider of all medications, supplements, and herbal products being taken to avoid potential interactions.

Storage:

• Store at room temperature (15-30°C or 59-86°F) in a dry place, away from direct light and moisture.
• Keep out of reach of children.

Packaging:

Hydroxychloroquine 200mg Tablets are typically packaged in blister packs or bottles, with quantities depending on the prescribed treatment plan.