Levofloxacin 750mg (Levoflox) Tablets

Levofloxacin 750mg (Levoflox) Tablets are a potent fluoroquinolone antibiotic used to treat a variety of bacterial infections. Levofloxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication, transcription, and repair, ultimately leading to the death of susceptible bacteria.

Indications:

Levofloxacin 750mg is indicated for the treatment of the following infections:

• Respiratory Tract Infections: Including community-acquired pneumonia, acute exacerbations of chronic bronchitis, and sinusitis.
• Urinary Tract Infections: Such as complicated urinary tract infections and acute pyelonephritis.
• Skin and Soft Tissue Infections: Including complicated skin and skin structure infections.
• Bone and Joint Infections: Such as osteomyelitis.
• Intra-abdominal Infections: In combination with other antibacterial agents.

Dosage and Administration:

• Recommended Dosage: The typical adult dosage is 750mg taken once daily. The specific dosage may be adjusted based on the type and severity of the infection, as well as renal function.
• Duration of Treatment: Treatment duration usually ranges from 5 to 14 days, depending on the type of infection and clinical response.
• Administration: Levofloxacin tablets can be taken with or without food. It is advisable to take them at the same time each day for optimal therapeutic levels.

Contraindications:

• Hypersensitivity to levofloxacin or other fluoroquinolone antibiotics.
• A history of tendon disorders associated with fluoroquinolone use.

Precautions:

• Renal Impairment: Dose adjustment may be necessary in patients with renal dysfunction.
• QT Interval Prolongation: Caution is advised in patients with a history of arrhythmias or those taking medications that prolong the QT interval.
• Diabetes: Monitor blood glucose levels closely, as fluoroquinolones can cause changes in blood sugar.

Side Effects:

Common side effects may include:

• Nausea and vomiting
• Diarrhea
• Dizziness
• Headache
• Insomnia

Serious side effects (seek immediate medical attention if these occur):

• Allergic reactions (e.g., rash, itching, swelling of the face, lips, or throat, difficulty breathing)
• Tendon rupture or pain (particularly in the Achilles tendon)
• Severe gastrointestinal symptoms (e.g., persistent diarrhea, bloody stools)

Drug Interactions:

• Levofloxacin may interact with other medications, including antacids, sucralfate, and certain antiarrhythmics. Always inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.

Storage:

• Store at room temperature (15-30°C or 59-86°F) in a dry place, away from direct light and moisture.
• Keep out of reach of children.

Packaging:

Levofloxacin 750mg Tablets are typically available in blister packs or bottles, with quantities based on the prescribed treatment regimen.