Hydroxychloroquine 200mg Tablets

Hydroxychloroquine 200mg Tablets are an antimalarial medication primarily used for the prevention and treatment of malaria, as well as for managing autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine belongs to the class of drugs known as 4-aminoquinolines and is known for its immunomodulatory effects, which help in reducing inflammation and modulating the immune response.

Indications:

Hydroxychloroquine is indicated for the treatment of:

• Malaria: Used in both the prophylaxis and treatment of malaria caused by Plasmodium species, especially in areas where resistance to chloroquine has not been reported.
• Rheumatoid Arthritis: Helps alleviate symptoms such as pain and inflammation in adult patients.
• Systemic Lupus Erythematosus (SLE): Used to manage flares and reduce disease activity in patients with lupus.

Dosage and Administration:

• The recommended dosage of Hydroxychloroquine 200mg varies based on the condition being treated:
  • For Malaria Prevention: Typically, 400 mg (two 200 mg tablets) taken once a week, starting 1-2 weeks before exposure to malaria and continuing for 4 weeks after leaving the area.
  • For Acute Malaria Treatment: A loading dose may be given, followed by a specific dosage regimen based on weight and clinical guidelines.
  • For Rheumatoid Arthritis and SLE: The typical starting dose is 400-600 mg daily (two to three 200 mg tablets), which may be adjusted based on clinical response.
• Hydroxychloroquine should be taken with food or milk to reduce gastrointestinal side effects.

Contraindications:

• Hypersensitivity to hydroxychloroquine or any components of the formulation.
• Pre-existing retinal or visual field changes associated with previous use of 4-aminoquinolines.

Precautions:

• Ophthalmologic Monitoring: Regular eye examinations are recommended due to the risk of retinal toxicity, especially with long-term use.
• Cardiovascular Considerations: Use with caution in patients with a history of cardiac arrhythmias or those taking medications that may prolong the QT interval.
• Pregnancy and Lactation: Hydroxychloroquine may be used during pregnancy if the benefits outweigh the risks, but it should be discussed with a healthcare provider.

Side Effects:

Common side effects may include:

• Nausea and vomiting
• Diarrhea
• Stomach cramps
• Headache
• Dizziness

Serious side effects (seek immediate medical attention if these occur):

• Vision changes (e.g., blurred vision, difficulty seeing)
• Severe skin reactions (e.g., rash, itching, blistering)
• Muscle weakness or pain
• Symptoms of liver toxicity (e.g., jaundice, dark urine)

Drug Interactions:

• Hydroxychloroquine may interact with other medications, including certain antiepileptics and drugs that affect heart rhythm. Always inform your healthcare provider about all medications and supplements you are taking.

Storage:

• Store at room temperature (15-30°C or 59-86°F), away from moisture and direct light.
• Keep out of reach of children.

Packaging:

Hydroxychloroquine 200mg Tablets are available in blister packs or bottles, with quantities determined by the prescribed treatment regimen.