Pirfenex 200mg Tablets contain the active ingredient pirfenidone, a novel antifibrotic agent used in the treatment of idiopathic pulmonary fibrosis (IPF). Pirfenidone works by modulating various biological processes that contribute to fibrosis, thereby helping to slow down disease progression and improve lung function in patients with IPF.
Indications:
Pirfenex 200mg Tablets are indicated for the treatment of:
- Idiopathic Pulmonary Fibrosis (IPF): A progressive and debilitating lung disease characterized by the accumulation of fibrous tissue in the lungs, leading to respiratory difficulties and decreased lung function.
Dosage and Administration:
- The typical recommended dosage of Pirfenex is 600 mg three times a day (total of 1800 mg daily), taken with food to improve absorption and reduce gastrointestinal side effects.
- The treatment should be initiated at a lower dose and gradually increased to the target dose, depending on the patient’s tolerance and response.
- Dosage adjustments may be necessary for patients with hepatic impairment or those experiencing side effects.
Contraindications:
- Hypersensitivity to pirfenidone or any of its components.
- Patients with severe liver impairment (Child-Pugh Class C).
Precautions:
- Liver Function: Regular monitoring of liver function tests is recommended, as Pirfenex can cause liver enzyme elevations.
- Photosensitivity: Patients should be advised to avoid excessive sun exposure and use sun protection, as pirfenidone may increase sensitivity to sunlight.
- Pregnancy and Breastfeeding: The use of pirfenidone during pregnancy and breastfeeding should be approached with caution. It is advised to consult a healthcare provider.
Side Effects:
Common side effects may include:
- Nausea and vomiting
- Diarrhea
- Fatigue
- Anorexia (loss of appetite)
- Rash or skin reactions
Serious side effects (seek medical attention if these occur):
- Liver function abnormalities (elevated liver enzymes)
- Severe skin reactions
- Respiratory complications or worsening of pulmonary symptoms
- Signs of an allergic reaction (e.g., swelling, difficulty breathing)
Drug Interactions:
- Pirfenidone may interact with medications that affect liver enzymes (e.g., CYP450 inducers or inhibitors). Patients should inform their healthcare provider about all medications, supplements, and herbal products they are using to avoid potential interactions.
Storage:
- Store at room temperature (15-30°C or 59-86°F), in a dry place away from light and moisture.
- Keep out of reach of children.
Packaging:
Pirfenex 200mg Tablets are typically available in blister packs or bottles, with quantities based on the prescribed treatment regimen.
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