Sitagliptin 100mg + Metformin 1000mg Janumet XR/CP Tablets

Janumet XR/CP Tablets combine two active ingredients, Sitagliptin and Metformin, to effectively manage blood glucose levels in adults with type 2 diabetes. Sitagliptin is a DPP-4 inhibitor that enhances the body’s natural ability to lower blood sugar by increasing incretin levels, which help regulate glucose metabolism. Metformin is a biguanide that improves insulin sensitivity, decreases hepatic glucose production, and enhances glucose uptake and utilization in peripheral tissues.

Indications:

• Management of blood sugar levels in adults with type 2 diabetes mellitus, particularly in combination with diet and exercise.
• Can be used as a second-line treatment in patients not adequately controlled on Metformin alone.

Dosage and Administration:

• The usual starting dose is one tablet (Sitagliptin 100mg + Metformin 1000mg) taken once daily with food to reduce the risk of gastrointestinal side effects.
• Dosage may be adjusted based on blood glucose levels, tolerability, and physician recommendations.
• Patients should adhere to their prescribed diet and exercise regimen to maximize the therapeutic effects.

Contraindications:

• Hypersensitivity to Sitagliptin, Metformin, or any of the excipients.
• Severe renal impairment or acute or chronic metabolic acidosis, including diabetic ketoacidosis.
• Patients undergoing procedures that require contrast media administration should discontinue the use of Metformin before and for 48 hours after the procedure.

Precautions:

• Regular monitoring of renal function is recommended, as Metformin is contraindicated in patients with renal impairment.
• Caution in patients with a history of pancreatitis, as there is a potential risk of developing pancreatitis with DPP-4 inhibitors.
• Alcohol consumption should be limited, as it can increase the risk of lactic acidosis.
• Pregnant or breastfeeding women should consult their healthcare provider before use.

Side Effects:
Common side effects may include:

• Nausea
• Diarrhea
• Stomach pain
• Headache

Serious but less common side effects include:

• Lactic acidosis, a rare but serious condition that can occur with Metformin.
• Pancreatitis, which may present as severe abdominal pain, nausea, and vomiting.
• Hypoglycemia, especially if used with other antidiabetic medications.

Drug Interactions:

• Certain medications may increase the risk of lactic acidosis or affect glucose levels, including diuretics, corticosteroids, and other antihyperglycemic agents.
• Inform your healthcare provider of all medications, supplements, or herbal products being taken to avoid potential interactions.

Storage:

• Store at room temperature, below 30°C (86°F), away from moisture and heat.
• Keep out of reach of children.

Packaging:
Available in blister packs, with each tablet containing 100mg of Sitagliptin and 1000mg of Metformin Hydrochloride.