Valacyclovir 1000mg (Valcivir) Tablets

Valacyclovir 1000mg (Valcivir) is an antiviral medication used primarily for the treatment of infections caused by certain viruses, particularly herpes simplex virus and varicella-zoster virus. Valacyclovir is a prodrug that is rapidly converted into acyclovir in the body, which interferes with viral DNA replication, thereby inhibiting the growth and spread of the virus. This medication is effective in managing conditions such as genital herpes, cold sores, and shingles.

Indications:

Valacyclovir 1000mg (Valcivir) is indicated for:

• Treatment of initial and recurrent episodes of genital herpes in adults.
• Suppressive therapy for recurrent genital herpes.
• Treatment of herpes zoster (shingles) in adults.
• Treatment of cold sores (herpes labialis) in adults.
• Reduction of the risk of transmission of genital herpes to uninfected partners.

Dosage and Administration:

• Recommended Dosage for Genital Herpes: The usual dose for the treatment of an initial episode is 1,000mg taken twice daily for 7 to 10 days. For recurrent episodes, the recommended dose is 500mg taken twice daily for 3 to 5 days.
• Recommended Dosage for Suppressive Therapy: The usual dose is 500mg to 1,000mg taken once daily, depending on the frequency of outbreaks.
• Recommended Dosage for Herpes Zoster: The recommended dose is 1,000mg taken three times daily for 7 days.
• Recommended Dosage for Cold Sores: The typical dose is 2,000mg taken at the first sign of symptoms, followed by a second dose 12 hours later (do not take more than two doses in one day).

Valacyclovir should be taken orally with or without food. It is important to stay well-hydrated during treatment.

Contraindications:

• Hypersensitivity to Valacyclovir, Acyclovir, or any of its components
• Patients with severe renal impairment should use Valacyclovir with caution, and dosage adjustments may be necessary.

Precautions:

• Caution is advised in patients with a history of renal impairment, dehydration, or concurrent use of nephrotoxic medications.
• Patients should be informed about the importance of adhering to therapy and the need for safe practices to reduce the risk of transmission of genital herpes.

Side Effects:

Common side effects may include:

• Nausea
• Headache
• Dizziness
• Fatigue
• Abdominal pain

Serious side effects (seek medical attention if these occur):

• Severe allergic reactions (rash, itching, swelling, difficulty breathing)
• Signs of kidney dysfunction (decreased urination, swelling in the legs or feet)
• Neuropsychiatric events (confusion, hallucinations, agitation)

Drug Interactions:

• Valacyclovir may interact with other medications that affect kidney function. Patients should inform their healthcare provider of all medications they are taking.
• Probenecid can increase Valacyclovir levels in the blood, requiring careful monitoring and possible dosage adjustments.

Storage:

• Store at room temperature, away from direct sunlight and moisture.
• Keep out of reach of children.

Packaging:

• Valacyclovir 1000mg (Valcivir) is available in blister packs or bottles, typically containing 10 or more tablets.